UV Spectrophotometric Method for Determination of the Dissolution Profile of Rivaroxaban


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ÇELEBİER M., KAYNAK M. S., ALTINÖZ S., ŞAHİN S.

DISSOLUTION TECHNOLOGIES, vol.21, no.4, pp.56-59, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.14227/dt210414p56
  • Journal Name: DISSOLUTION TECHNOLOGIES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.56-59
  • Hacettepe University Affiliated: Yes

Abstract

Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the amount of rivaroxaban released in tablet dissolution studies. The dissolution profile of rivaroxaban was successfully determined with the validated method.