Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies

Karuppasamy M., Mahapatra M., YABANOĞLU ÇİFTÇİ S., UÇAR G., Sinha B. N., Basu A., ...More

BIOORGANIC & MEDICINAL CHEMISTRY, vol.18, no.5, pp.1875-1881, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1016/j.bmc.2010.01.043
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1875-1881
  • Hacettepe University Affiliated: Yes


3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 10(3)-10(5). The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (K-i) values obtained by molecular docking studies were in congruence with their experimental (K-i) values. (C) 2010 Elsevier Ltd. All rights reserved.