Synthesis and evaluation of antimicrobial activity of new 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide derivatives

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Aytemir M., EROL D., HIDER R., Özalp M.

TURKISH JOURNAL OF CHEMISTRY, vol.27, no.6, pp.757-764, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1080/14786419.2018.1440224
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.757-764
  • Hacettepe University Affiliated: Yes


The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2-carboxamide with antimicrobial activity is described. Amide derivatives of pyranone were synthesised using TBTU [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as a base. Antimicrobial activities were determined as MIC values using the microdilution broth method against Staphylococcus aureus, Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for bacteria and Candida albicans, C. krusei and C. parapsilosis for fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2[N-(4'-methylcoumarin-7-yl)carboxamide] (8c) exhibited higher antibacterial activity against S. aureus, E. faecalis and E. coli than the other compounds. In addition, 8c was more active against C. krusei than the other synthesised compounds.