Anti-inflammatory effects of oral and intraperitoneal administration of cerium oxide nanoparticles on experimental hepatic ischemia-reperfusion injury

Zengin A., ERİKÇİ A., TELLİ G., GÜMÜŞEL B., KÖSEMEHMETOĞLU K., UÇAR G., ...Daha Fazla

TURKISH JOURNAL OF SURGERY, cilt.38, sa.3, ss.255-265, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.47717/turkjsurg.2022.5620
  • Dergi Adı: TURKISH JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.255-265
  • Anahtar Kelimeler: Ischemia reperfusion, cerium oxide nanoparticles (CONPs), mouse, oxidative stress, inflammation, ISCHEMIA/REPERFUSION INJURY, MECHANISMS, SEVOFLURANE, INHIBITION, TISSUE, MODEL
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Hepatic ischemia-reperfusion (IR) injury occurs in liver surgery, resection, and transplantation. Reactive oxygen species (ROS) produced following IR starts the cascade of cell damage, necrosis/apoptosis, and proinflammatory responses by activating intracellular signaling cascade to drive hepatocellular damage. Cerium oxide nanoparticles (CONPs) act as anti-inflammatory and antioxidant agents. Thus, we evaluated the protective effects of oral (o.g.) and intraperitoneal (i.p.) administration of CONPs on hepatic IR injury.