Sedative effect of Centranthus longiflorus ssp longiflorus in rats and the influence of adrenalectomy on its effect

SULEYMAN, LÜTFİYE; Guvenalp, Zuhal; KIZILKAYA, Mehmet; Demirezer, L.

doi:10.1248/yakushi.127.1263

Sedative effect of Centranthus longiflorus ssp longiflorus in rats and the influence of adrenalectomy on its effect

Atıf İçin Kopyala

SULEYMAN H., Guvenalp Z., KIZILKAYA M., Demirezer L. O.

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, cilt.127, sa.8, ss.1263-1265, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 127 Sayı: 8
Basım Tarihi: 2007
Doi Numarası: 10.1248/yakushi.127.1263
Dergi Adı: YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1263-1265
Hacettepe Üniversitesi Adresli: Evet

Özet

Sedative effect of the aqueous extract of Centranthus longiflorus ssp. longiflorus (Cle-1) on intact and adrenalectomized rats was investigated using a thiopental sleeping test to clarify the relationship of this effect on adrenal gland hormones, particularly glucocorticoids. Adrenal gland hormones were found to play an important role in inhibiting the sedative effect of the investigated drugs. It is clear, however, that these hormones are not glucocorticoids. Glucocorticoids were not responsible for shortening the sleep period.