Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity

AYTEMİR M., Ozcelik B., Karakaya G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.12, pp.3646-3649, 2013 (SCI-Expanded) identifier identifier identifier


In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum. (C) 2013 Elsevier Ltd. All rights reserved.