CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies


van der Zanden L. F. M., van Rooij I. A. L. M., Quaedackers J. S. L. T., Nijman R. J. M., Steffens M., de Wall L. L. L., ...Daha Fazla

EUROPEAN UROLOGY OPEN SCIENCE, cilt.28, ss.26-35, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.euros.2021.04.001
  • Dergi Adı: EUROPEAN UROLOGY OPEN SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.26-35
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.