Atorvastatin efficiency after traumatic brain injury in rats

TURKOGLU O. F., EROĞLU H., OKUTAN O., GURCAN O., BODUR E., SARGON M. F., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.72, sa.2, ss.146-152, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.surneu.2008.07.004
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.146-152
  • Anahtar Kelimeler: Atorvastatin, Brain edema, Traumatic brain injury, Lipid peroxidation, DEXAMETHASONE SODIUM-PHOSPHATE, NERVOUS-SYSTEM, NITRIC-OXIDE, CEREBRAL-ISCHEMIA, CORTICAL-NEURONS, BLOOD-FLOW, STROKE, SUPEROXIDE, MECHANISMS, STATINS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: The neuroprotective effects of statins possibly depend on their pleiotropic effect such as antioxidative and anti-inflammatory properties. In this study, we have evaluated the efficiency of atorvastatin on brain edema, lipid peroxidation, and ultrastructural changes in TBI animal model.