Atorvastatin efficiency after traumatic brain injury in rats

TURKOGLU O. F., EROĞLU H., OKUTAN O., GURCAN O., BODUR E., SARGON M. F., ...More

SURGICAL NEUROLOGY, vol.72, no.2, pp.146-152, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.surneu.2008.07.004
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.146-152
  • Keywords: Atorvastatin, Brain edema, Traumatic brain injury, Lipid peroxidation, DEXAMETHASONE SODIUM-PHOSPHATE, NERVOUS-SYSTEM, NITRIC-OXIDE, CEREBRAL-ISCHEMIA, CORTICAL-NEURONS, BLOOD-FLOW, STROKE, SUPEROXIDE, MECHANISMS, STATINS
  • Hacettepe University Affiliated: Yes

Abstract

Background: The neuroprotective effects of statins possibly depend on their pleiotropic effect such as antioxidative and anti-inflammatory properties. In this study, we have evaluated the efficiency of atorvastatin on brain edema, lipid peroxidation, and ultrastructural changes in TBI animal model.