Treatment of enteric fever with pefloxacin for 7 days versus 5 days: A randomized clinical trial

Unal S., HAYRAN M., TUNCER S., GUR D., Uzun O., Akova M., ...More

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.40, no.12, pp.2898-2900, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 12
  • Publication Date: 1996
  • Doi Number: 10.1128/aac.40.12.2898
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2898-2900
  • Hacettepe University Affiliated: Yes


In this prospective study of enteric fever, 22 patients received 400 mg of pefloxacin twice daily for 5 days (group A) and 24 received 400 mg of pefloxacin twice daily for 7 days (group B). Causative microorganisms were Salmonella typhi (8 in group A, 11 in group B) and Salmonella paratyphi B (14 in group A, 13 in group B). The clinical cure and bacterial eradication rates were 96% (21 of 22) in group A and 100% in group B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp.