Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities

Tozkoparan B., AKTAY G., YESILADA E., ERTAN M.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.51, sa.6, ss.470-477, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 6
  • Basım Tarihi: 2001
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.470-477
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, 21 new compounds having 2-methyl-6-benzylidenethiazolo [3,2-b]1,2,4-triazol 5(6H)-one (2-4) and 2-methyl-6- (alpha -aminobenzyl)thiazolo[3,2-b]-1,2,4-triazole-5-ol (2a-4g) structures were synthesized, The structures of the compounds were proved by spectral and elemental analysis. All of the compounds synthesized were tested for their anti-inflammatory activiy and ulcerogenic potential in mice at 10, 20 and 40 mg/kg dose Levels. Compound 4b showed higher anti-inflammatory activity than the analogue derivatives and indometacin (CAS 53-86-1), used as a reference drug, at 10 mg/kg dose Level. Generally, the compounds were found to be more reliable than indometacin since they did not cause any reaction in the stomach.