The role of SPINK5 in asthma related physiological events in the airway epithelium

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BİRBEN E., Sackesen C., TURGUTOĞLU N., Kalayci O.

RESPIRATORY MEDICINE, cilt.106, sa.3, ss.349-355, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 106 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.rmed.2011.11.007
  • Dergi Adı: RESPIRATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.349-355
  • Anahtar Kelimeler: Apoptosis, Cytokine, Mucus production, Protease inhibitors, SPINK5, PROTEASE-ACTIVATED RECEPTOR-2, HUMAN LUNG FIBROBLASTS, SERINE-PROTEASE, ATOPIC-DERMATITIS, CELLS, INHIBITOR, INTERLEUKIN-8, INFLAMMATION, TRYPTASE, RELEASE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Genetic studies have shown that variants in SPINK5 may be associated with atopic diseases and asthma. However, the functional role of SPINK5 protein in asthma has not been elucidated.