A correlation study of fluorouracil pharmacodynamics with clinical efficacy and toxicity

Esin E., Telli T. A., YÜCE D., YALÇIN Ş.

TUMORI J, cilt.104, sa.3, ss.157-164, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 104 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5301/tj.5000652
  • Dergi Adı: TUMORI J
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.157-164
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Plasma 5-fluorouracil (5-FU) concentrations vary greatly between individuals who have received standard dosage. Pharmacokinetic adjusted doses have been hypothesized to overcome the possibility of potential toxicity and ineffectiveness related to inappropriate plasma levels of 5-FU. In this study, we prospectively investigated the clinical benefit and toxicity of 5-FU in relation to its pharmacokinetic properties.