Comparison of extraarticular leakage values of radiopharmaceuticals used for radionuclide synovectomy


Gedik G., Ugur Ö., Atilla B., Pekmezci M., Yildirim M., Seven B., ...Daha Fazla

ANNALS OF NUCLEAR MEDICINE, cilt.20, sa.3, ss.183-188, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/bf03027428
  • Dergi Adı: ANNALS OF NUCLEAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-188
  • Anahtar Kelimeler: Y-90-citrate, Y-90-silicate, Re-186-sulfide, chronic synovitis, radionuclide synovectomy, RADIATION SYNOVECTOMY, RADIO SYNOVECTOMY, RADIOSYNOVIORTHESIS, SYNOVITIS, KNEE, Y-90, HEMOPHILIA, DOSIMETRY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives: Radionuclide synovectomy is a reliable therapy in patients with chronic synovitis. However, radiation doses delivered to non-target organ systems due to leakage of radioactive material from the articular cavity are an important disadvantage of this procedure. In this study we compared extraarticular leakage values of the 3 commonly used radiopharmaceuticals; Y-90-citrate, Y-90-silicate and Re-186-sulfide colloid. Materials and Methods: Thirty-five patients with persistent synovitis were enrolled in the study. Twenty-two hemophilic, 8 rheumatoid arthritis and 5 patients with pigmented villonodular synovitis were studied. Y-90 labeled silicate and citrate were used for knee joints and 186Re-sulfide for intermediate sized joints. Radiocolloid leakage values were evaluated using a gamma camera with 20% window centered over the bremsstrahlung photopeak of Y-90 and a respective window over the 137 keV photopeak of Re-186. Regions of interest were drawn over the injection site, the regional lymph nodes and the background areas. Leakage of radiocolloid was calculated by dividing the counts/pixel in the regional lymph node area to the counts/pixel in the injection site. Results: No visible leakage was observed. The median leakage values calculated for Y-90-citrate, Y-90-silicate and Re-186-sulfide were found as 1.9%, 2.4% and 2.7%, respectively. The difference between the variability of leakage values was not statistically significant (p > 0.05). Conclusion: There was no significant difference in terms of extraarticular leakage between Y-90-citrate, Y-90-silicate and Re-186-sulfide radiocolloids.