One of the candidate methods for new generation communication systems is orthogonal frequency division multiplexing with offset quadrature amplitude modulation (OFDM/OQAM). Because of its unique feature "intrinsic interference", new channel estimation methods have been developed for OFDM/OQAM. One of these is the interference cancellation method (ICM) which aims to eliminate the intrinsic interference. In the first studies related with ICM in the literature, "isotropic orthogonal transformation algorithm" (IOTA) was used as the waveform. However, these methods are valid only for isotropic waveforms. In this study, a new ICM preamble which suitable for both isotropic and anisotropic waveforms is proposed and the relation between isotropy of waveforms and ICM is discussed. The performance of the method against noise and peak to average power ratio (PAPR) of the method are examined via the simulations.