Does Defective Apoptosis Play A Role in Cystic Fibrosis Lung Disease?

Yalcin E., TALİM B., Ozcelik U., DOĞRU ERSÖZ D., Cobanoglu N., Pekcan S., ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.40, sa.7, ss.561-564, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 7
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.arcmed.2009.07.005
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.561-564
  • Anahtar Kelimeler: Apoptosis, Bronchiectasis, Bronchopneumonia, Cystic fibrosis, Lung, TRANSMEMBRANE CONDUCTANCE REGULATOR, RESPIRATORY EPITHELIAL-CELLS, EXPRESSION, INDUCTION, DNA, FAS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background and Aims. Although apoptotic dysfunction has recently been suggested in cystic fibrosis (CF), there are few studies reported concerning apoptosis in CF with controversial results. The aim of this study was to investigate apoptosis in CF human lung tissues and compare with non-CF bronchiectatic and normal healthy lung tissues. We also investigated the relation between apoptosis and histopathological features of tissues and microbiological factors influencing apoptosis.