Design, Synthesis and hMAO Inhibitory Screening of Novel 2-Pyrazoline Analogues

Evranos-Aksoz B., UÇAR G., YELEKÇİ K.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol.20, no.6, pp.510-521, 2017 (SCI-Expanded) identifier identifier identifier


Aim and Objective: MAO inhibitors have a significant effect on the nervous system since they act in regulation of neurotransmitter concentrations. Neurotransmitter levels are critical for a healthy nervous system. MAO inhibitors can be used in the treatment of neurological disorders such as depression, Parkinson's disease and Alzheimer's disease, as the increase or decrease of some neurotransmitter concentrations is associated with these neurological disorders. This study was conducted to discover new and active MAO inhibitor drug candidates.