ESTROGENS: PRODUCTION, FUNCTIONS AND APPLICATIONS, ss.169-181, 2009 (SCI-Expanded)
Estrogen treatment is rarely indicated during childhood. A limited number of patients requires either topical or systemic estrogens in selected cases. Labial adhesions in which the labia minora fused over the vestibule is the most common indication for topical estrogen treatment in children. Although the most accepted theory of labial adhesions is low estrogen levels, the use of topical estrogen treatment is still controversial.