DIAGNOSING SARCOPENIA: FUNCTIONAL PERSPECTIVES AND A NEW ALGORITHM FROM ISarcoPRM

KARA M., KAYMAK B., Frontera W. R., Merve A., Ricci V., Ekiz T., ...More

JOURNAL OF REHABILITATION MEDICINE, vol.53, no.6, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 53 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.2340/16501977-2851
  • Journal Name: JOURNAL OF REHABILITATION MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ASSIA, BIOSIS, CINAHL, EMBASE, MEDLINE, SportDiscus, Directory of Open Access Journals
  • Keywords: ultrasound, quadriceps, muscle, Sonographic Thigh Adjustment Ratio, function, frailty, Internatioanl Society of Physical and Rehabilitation Medicine, RENIN-ANGIOTENSIN SYSTEM, SKELETAL-MUSCLE MASS, LOWER-EXTREMITY FUNCTION, ASIAN WORKING GROUP, GAIT SPEED, PHYSICAL PERFORMANCE, OLDER PERSONS, SUBSEQUENT DISABILITY, COMPUTED-TOMOGRAPHY, PROGNOSTIC VALUE
  • Hacettepe University Affiliated: Yes

Abstract

Sarcopenia is an important public health problem, characterized by age-related loss of muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and premature death. Muscle loss is mainly due to the loss of type II mus-cle fibres, and progressive loss of motor neurones is thought to be the primary underlying factor. Ante-rior thigh muscles undergo atrophy earlier, and the loss of anterior thigh muscle function may therefore be an antecedent finding. The aim of this review is to provide an in-depth (and holistic) neuromusculoske-letal approach to sarcopenia. In addition, under the umbrella of the International Society of Physical and Rehabilitation Medicine (ISPRM), a novel diagnostic algorithm is proposed, developed with the consen-sus of experts in the special interest group on sar-copenia (ISarcoPRM). The advantages of this algo-rithm over the others are: special caution concerning disorders related to the renin-angiotensin system at the case finding stage; emphasis on anterior thigh muscle mass and function loss; incorporation of ul-trasound for the first time to measure the anterior thigh muscle; and addition of a chair stand test as a power/performance test to assess anterior thigh muscle function. Refining and testing the algorithm remains a priority for future research.