Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives


Musdal Y., Ertan-Bolelli T., Bolelli K., Yilmaz S., Ceyhan D., Hegazy U., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.37, sa.4, ss.431-436, 2012 (SCI-Expanded) identifier identifier

Özet

Objective: Glutathione transferases (GST) are multifunctional enzymes involved in detoxication, drug resistance, cell signaling and apoptosis. The inhibitory effects of novel benzazole derivatives were tested on human GST P1-1 to find new agents for overcoming drug resistance in cancer cells.