Effect of intermedin/adrenomedullin(2) on the pulmonary vascular bed in hypoxia-induced pulmonary hypertensive rats

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Telli G., Tel B. C., Yersal N., Korkusuz P., Gumusel B.

LIFE SCIENCES, vol.192, pp.62-67, 2018 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 192
  • Publication Date: 2018
  • Doi Number: 10.1016/j.lfs.2017.11.031
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.62-67
  • Keywords: Intermedin/adrenomedullin(2), Hypoxia-induced pulmonary hypertension, Isolated rat lung, Pulmonary artery, GENE-RELATED PEPTIDE, ARTERIAL-HYPERTENSION, NITRIC-OXIDE, FAMILY PEPTIDE, ADRENOMEDULLIN, VASODILATION, INTERMEDIN, MAMMALS, PATHWAY
  • Hacettepe University Affiliated: Yes

Abstract

Aims: This study aimed to investigate the effect and mechanism of action of intermedin/adrenomedullin2 (IMD/AM(2)) on the pulmonary vascular bed in pulmonary hypertensive rats.