Scintigraphic imaging of radiolabelled drug delivery systems in rabbits with arthritis


Turker S., Erdogan S. , Ozer Z. , Ergun E., Tuncel M. , Bilgili H., ...More

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.296, no.1-2, pp.34-43, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 296 Issue: 1-2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.ijpharm.2005.02.017
  • Title of Journal : INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Page Numbers: pp.34-43
  • Keywords: intra-articular drug delivery, scintigraphic imaging, drug delivery systems, rheumatoid arthritis, diclofenac sodium, ANTIGEN-INDUCED ARTHRITIS, LIPOSOMES, THERAPY, DICLOFENAC, CLODRONATE, RELEASE

Abstract

This paper describes a novel approach for designing drug delivery systems for intra-articular (i.a.) treatment of rheumatoid arthritis. Retention of these systems was evaluated by radiolabeling with Tc-99m and gamma scintigraphy in arthritic rabbits. Liposome, niosome, lipogelosome and niogelosome formulations of Diclofenac Sodium (DFNa) have been prepared and drug release properties and in vitro characterisation studies have been carried out. According to characterisation results L1 (DMPC: CHOL DCP (7:1:2)), L1J1 (DMPC: CHOL DCP (7:1:2) in C-940 1:1 (w/w)), N (SUR I: CHOL: DCP (7:1:2)) and NJ1 (SUR I: CHOL: DCP (7:1:2) in C-940 1:1 (w/w)) formulations were chosen for the further studies. Retention time of these formulations was evaluated by gamma scintigraphic imaging studies. Rabbits with antigen-induced arthritis were injected intra-articularly with Tc-99m labelled drug delivery systems. Serial scintigraphic images were obtained to investigate the retentions of labelled drug delivery systems in the arthritic joints and choose a suitable formulation for the treatment protocol of arthritis.