Effects of endothelin receptor blockade and COX inhibition on intestinal I/R injury in a rat model: Experimental research

Ucar B. I., Erikci A., Kosemehmetoglu K., Ozkul C., Iskit A. B., Ucar G., ...Daha Fazla

INTERNATIONAL JOURNAL OF SURGERY, cilt.83, ss.89-97, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 83
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ijsu.2020.08.061
  • Dergi Adı: INTERNATIONAL JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.89-97
  • Anahtar Kelimeler: Intestinal ischemia reperfusion injury, Rat, Cyclooxygenase inhibition, Endothelia receptor blockers, Nitric oxide
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. The present study aimed to investigate the effects of cyclooxygenase (COX) inhibition synchronized with nitric oxide (NO) release and endothelin (ET) receptor blockade on oxidative stress, inflammation, vasoconstriction, and bacterial translocation which occur during ischemia-reperfusion (I/R) injury in in-vivo rat intestinal I/R model.