CYTOTOXIC ACTIVITY STUDIES OF SOME PLATINUM(II) COMPLEXES WITH 2-SUBSTITUTEDBENZIMIDAZOLE LIGANDS

ÖZÇELİK A. B., GÜMÜŞ F., KILIÇ SÜLOĞLU A., SELMANOĞLU G.

REVUE ROUMAINE DE CHIMIE, vol.64, no.9, pp.829-834, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 9
  • Publication Date: 2019
  • Doi Number: 10.33224/rrch.2019.64.9.10
  • Journal Name: REVUE ROUMAINE DE CHIMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.829-834
  • Hacettepe University Affiliated: Yes

Abstract

In the present study, two Pt( II) complexes with 2-substitutedbenzimida-zole ligands were synthesized and evaluated for their in vitro cytotoxic activities on HeLa and MCF-7 cell lines. 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test results showed that complex 2 which was found to be the more active than carboplatin was the most cytotoxic active compound against the HeLa and MCF-7 cell lines among the tested compounds.