Akademik Veri Yönetim Sistemi
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2025 (SCI-Expanded)
Background: Epidemiological studies of neuromyelitis optica spectrum disorder (NMOSD) show variability due to differences in methodologies, diagnostic criteria, and geographic factors. Objective: This study aimed to determine NMOSD's epidemiological profile in T & uuml;rkiye using official health records covering over 95 % of the population. Methods: Data were collected using ICD-10 codes (G36.0) from the Health Record Reporting System (HRRS). Patients with at least three G36.0 codes or one G36.0 code combined with a prescription for rituximab, eculizumab, or tocilizumab were included. Nationwide prevalence of NMOSD in 2022 and incidence (2018-2022) were calculated using census data. Results: We identified 1,623 patients meeting inclusion criteria. The prevalence was 1.9 per 100,000, and the incidence in 2022 was 2.1 per 1,000,000. A decreasing prevalence gradient from east to west was observed. The mean (+/- SD) patient age was 44.2 +/- 15.7 years. Among 193 aquaporin-4 antibody positive patients, the femaleto-male ratio was 8.2. Additionally, 83 % received at least one disease-modifying treatment. Conclusion: NMOSD epidemiological features in T & uuml;rkiye align with European data but remain lower than figures reported in African and Asian populations. Further research is needed to enhance the understanding of NMOSD in this population.