HPV types and E6/E7 mRNA expression in cervical samples from Turkish women with abnormal cytology in Ankara, Turkey

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Tuney I., Altay A., ERGÜNAY K., ÖNDER S. Ç., USUBÜTÜN A., SALMAN M. C., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.1, pp.194-200, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1508-155
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.194-200
  • Keywords: Cervical cancer, cytology, HPV DNA test, E6/E7 mRNA, HUMAN-PAPILLOMAVIRUS INFECTION, INTRAEPITHELIAL NEOPLASIA, NATURAL-HISTORY, CANCER, DNA, CLASSIFICATION, PERFORMANCE, LESIONS, RISK
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: Human papillomaviruses have been established as a risk factor for invasive carcinoma of the uterine cervix. HPV E6/E7 oncogene expression has recently emerged as a promising biomarker to determine the risk for progression to high-grade cervical lesions. The aim of this study was to evaluate HPV mRNA and DNA detection in samples with abnormal cytology.