ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.1, ss.79-84, 2021 (ESCI)
Background and Aims: Antibiotic resistance is one of the most critical global health problems. Understanding the pathogen -antibiotic relationship at molecular level could lead to the discovery of new routes to overcome antibiotic resistance. In our present work, we evaluated early responses of E. coli against ciprofloxacin within 30 min by analyzing metabolome structure. Our main goal was to understand the initial steps of the adaptation and resistance process of pathogens under antibiotic stress.