Short-term adaptive metabolic response of Escherichia coli to ciprofloxacin exposure


KOÇAK E. , ÖZKUL KOÇAK C.

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.1, pp.79-84, 2021 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2020.0069
  • Title of Journal : ISTANBUL JOURNAL OF PHARMACY
  • Page Numbers: pp.79-84

Abstract

Background and Aims: Antibiotic resistance is one of the most critical global health problems. Understanding the pathogen -antibiotic relationship at molecular level could lead to the discovery of new routes to overcome antibiotic resistance. In our present work, we evaluated early responses of E. coli against ciprofloxacin within 30 min by analyzing metabolome structure. Our main goal was to understand the initial steps of the adaptation and resistance process of pathogens under antibiotic stress.