Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis

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Bayrak A., Bayrak T., TOKGÖZOĞLU S. L., VOLKAN SALANCI B., Deniz A., YAVUZ B., ...Daha Fazla

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.19, sa.4, ss.376-384, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5551/jat.11320
  • Dergi Adı: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.376-384
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Aim: Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis. The aim of this study was to investigate the possible relationship between serum paraoxonase (PONase), homocysteine thiolactonase (HTase) activities and PON1 Q192R polymorphism, and the extent and severity of atherosclerosis.