Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment


Eroglu M. , Sezgin A., Semercioz A., Metin A., Kandirali E., Onur M. A.

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.39, no.1, pp.137-141, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1007/s11255-006-9047-z
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.137-141

Abstract

It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract. The aim of this study is to determine whether this up-regulation does have any effect on contractile response of rabbit bladder neck to adrenaline, acethylcholine and papaverin after long-term doxazosin treatment. Fourteen rabbits, treated with doxazosin 3 mg/kg/day p.o for 6 months, and were fed with a diet of standard laboratory rabbit chow (100 g/kg/day). Ten rabbits received the same amount of regular chow but no drug. Contractile responses of rabbit bladder neck to adrenaline acethylcholine and papaverine were measured.