FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1


Musdal Y. , Hegazy U. M. , AKSOY Y. , Mannervik B.

CHEMICO-BIOLOGICAL INTERACTIONS, vol.205, no.1, pp.53-62, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 205 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.cbi.2013.06.003
  • Title of Journal : CHEMICO-BIOLOGICAL INTERACTIONS
  • Page Numbers: pp.53-62

Abstract

Objective: Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. Inhibitors of GST P1-1 are expected to counteract drug resistance and may therefore serve as adjuvants in the chemotherapy of cancer by increasing the efficacy of cytostatic drugs. Finding useful inhibitors among compounds used for other indications would be a shortcut to clinical applications and a search for GST P1-1 inhibitors among approved drugs and other compounds was therefore conducted.