Thyrotropine releasing hormone accelerates wound healing in hyperglycemia inducted mouse fibroblast cell line

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DENİZALTI M., Kazkayasi I., TELLİ G.

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.3, pp.313-318, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.932945
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.313-318
  • Keywords: Hyperglycemia, wound healing, scratch migration assay, fibroblast, MARGINAL SCARS, PROLIFERATION, MIGRATION, GLUCOSE, BURNS
  • Hacettepe University Affiliated: Yes

Abstract

Background and Aims: It has been suggested that thyrotropin-releasing hormone (TRH) may have functions beyond its fundamental regulating function. Previous studies have demonstrated that TRH promotes wound healing. We aimed to perform an in vitro study in fibroblasts to assess the role of TRH in wounds that frequently occur in diabetes. Thus, we investigated the effects of TRH in wound healing both under normoglycemic and hyperglycemic-conditions.