Thyrotropine releasing hormone accelerates wound healing in hyperglycemia inducted mouse fibroblast cell line

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DENİZALTI M., Kazkayasi I., TELLİ G.

ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.3, ss.313-318, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/istanbuljpharm.2021.932945
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.313-318
  • Anahtar Kelimeler: Hyperglycemia, wound healing, scratch migration assay, fibroblast, MARGINAL SCARS, PROLIFERATION, MIGRATION, GLUCOSE, BURNS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background and Aims: It has been suggested that thyrotropin-releasing hormone (TRH) may have functions beyond its fundamental regulating function. Previous studies have demonstrated that TRH promotes wound healing. We aimed to perform an in vitro study in fibroblasts to assess the role of TRH in wounds that frequently occur in diabetes. Thus, we investigated the effects of TRH in wound healing both under normoglycemic and hyperglycemic-conditions.