Effects of flavonoid quercetin on survival of motor neuron gene expression.


Uzunalli G., Bora-Tatar G. , Dayangac-Erden D. , Erdem-Yurter H.

Cell biology international, vol.39, no.3, pp.350-4, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1002/cbin.10395
  • Title of Journal : Cell biology international
  • Page Numbers: pp.350-4

Abstract

Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that results in muscle weakness and atrophy. To attenuate disease severity, drug development studies have been applied mainly to target the Survival of Motor Neuron 2 (SMN2) gene, which is an important modifier of SMA. Although several compounds have been tested, there is still no cure for SMA. In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients. Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level.