Synthesis and biological activities of some thiazolidin-4-ones

Ozadah K., Ozkanh F., Erol D., Dogan A. E., Erol K.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.56, sa.10, ss.678-681, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 10
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1055/s-0031-1296772
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.678-681
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and a-mercaptoacetic acid. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, mass spectral data and elementary analysis. The antihist-aminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-[3-(2-methyl-piperidine-1-yl)propyl]-2-(4-methyl- phenyl)thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).

In this study, 15 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds determined by the tests performed on isolated guinea pig trachea in comparison with aminophilline (CAS number: 317-34-0). Compound 15, 3-[3-(2-methylpiperidine-1-yl)propyl]-2-(4-methylphenyl)thiazolidin-4-one hydrochloride, the highest inhibition (53 %).