Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population


IŞGIN ATICI K., Alathari B. E. , TURAN DEMİRCİ B., ŞENDUR S. N. , LAY İ., Ellahi B., ...More

NUTRIENTS, vol.14, no.2, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.3390/nu14020382
  • Journal Name: NUTRIENTS
  • Journal Indexes: Science Citation Index Expanded, Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: vitamin D, MC4R, genetic risk score, fat intake, metabolic traits, VITAMIN-D LEVELS, BODY-MASS INDEX, RECEPTOR GENE, INSULIN-RESISTANCE, CARDIOVASCULAR-DISEASE, D SUPPLEMENTATION, ADIPOSE-TISSUE, D DEFICIENCY, POLYMORPHISMS, ASSOCIATION

Abstract

Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24-50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS >= 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (P-interaction = 0.040). Participants carrying a metabolic-GRS >= 1 risk allele and consuming a high fat diet (>= 38% of energy = 122.3 +/- 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 +/- 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.