Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment

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Alp E., Damkaci F., GÜVEN E., Tenniswood M.

INTERNATIONAL JOURNAL OF NANOMEDICINE, cilt.14, ss.1335-1346, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2147/ijn.s191837
  • Dergi Adı: INTERNATIONAL JOURNAL OF NANOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1335-1346
  • Anahtar Kelimeler: cell cycle, apoptosis, DNA fragmentation, gene expression, epigenetics, MCF-7, SOLID LIPID NANOPARTICLES, DRUG-DELIVERY, POLYMERIC NANOPARTICLES, TRICHOSTATIN-A, CELL-CYCLE, APOPTOSIS, LIPOSOMES, GENE, NANOSPHERES, EXPRESSION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: The efficacy of epigenetic drugs, such as histone deacetylase inhibitors, is often diminished by poor aqueous solubility resulting in limited bioavailability and a low therapeutic index. To overcome the suboptimal therapeutic index, we have developed a biocompatible starch nanoparticle formulation of CG-1521, a histone deacetylase inhibitor in preclinical development for hard-to-treat breast cancers, which improves its bioavailability and half-life.