A case of chronic severe neutropenia: Oral findings and consequences of short-term granulocyte colony-stimulating factor treatment

Hasturk H., Tezcan I., Yel L., Ersoy F., Sanal O., Yamalik N., ...Daha Fazla

AUSTRALIAN DENTAL JOURNAL, cilt.43, sa.1, ss.9-13, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 1
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1111/j.1834-7819.1998.tb00144.x
  • Dergi Adı: AUSTRALIAN DENTAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-13
  • Anahtar Kelimeler: neutropenia, granulocyte-colony stimulating factor, periodontal breakdown, oral ulceration, paediatric dentistry, case report, CYCLIC NEUTROPENIA, PREPUBERTAL PERIODONTITIS, IDIOPATHIC NEUTROPENIA, DISEASE, PATIENT, ENTITY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Neutropenia is an absolute decrease in the number of circulating neutrophils in the blood which results in susceptibility to severe pyogenic infections. Various oral findings such as periodontitis, alveolar bone loss and ulceration may be seen in neutropenic patients. A case is presented of a 6 year old girl with chronic, probably congenital, severe neutropenia with frequent respiratory tract infections, recurrent oral ulcerations and significant periodontal breakdown resembling prepubertal periodontitis. She was given granulocyte-colony stimulating factor (G-CSF) treatment which resulted in an increase in granulocyte count within two weeks and resolution of the neutropenic ulceration. It is suggested that G-CSF together with dental care regimens is a promising treatment model in chronic severe neutropenia cases presenting with oral manifestations.