Glucagon-like peptide-1, a matter of taste?


Jensterle M., DeVries J. H., Battelino T., Battelino S., Yildiz B., Janez A.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, cilt.22, sa.4, ss.763-775, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s11154-020-09609-x
  • Dergi Adı: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.763-775
  • Anahtar Kelimeler: GLP-1, GLP-1 receptor agonists, Gustatory coding, Obesity, Taste, Tongue, GASTRIC BYPASS-SURGERY, SWEET TASTE, FOOD CRAVINGS, CIRCUMVALLATE PAPILLAE, ORBITOFRONTAL CORTEX, GLUCOSE-TOLERANCE, BUD MORPHOLOGY, CELL LINEAGE, BODY-WEIGHT, LOW-CALORIE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Understanding of gustatory coding helps to predict, and perhaps even modulate the ingestive decision circuitry, especially when eating behaviour becomes dysfunctional. Preclinical research demonstrated that glucagon like peptide 1 (GLP-1) is locally synthesized in taste bud cells in the tongue and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1 containing taste bud cells. In humans, the tongue has not yet been addressed as clinically relevant target for GLP-1 based therapies. The primary aim of the current review was to elaborate on the role of GLP- 1 in mammalian gustatory system, in particular in the perception of sweet. Secondly, we aimed to explore what modulates gustatory coding and whether the GLP-1 based therapies might be involved in regulation of taste perception. We performed a series of PubMed, Medline and Embase databases systemic searches. The Population-Intervention-Comparison-Outcome (PICO) framework was used to identify interventional studies. Based on the available data, GLP-1 is specifically involved in the perception of sweet. Aging, diabetes and obesity are characterized by diminished taste and sweet perception. Calorie restriction and bariatric surgery are associated with a diminished appreciation of sweet food. GLP-1 receptor agonists (RAs) modulate food preference, yet its modulatory potential in gustatory coding is currently unknown. Future studies should explore whether GLP-1 RAs modulate taste perception to the extent that changes of food preference and consumption ensue.