Procaine and saline have similar effects on articular cartilage and synovium in rat knee

Ankay Y., Akca B., Buyukakkus B., Bahador Z., Zeybek D., Uzumcugil F., ...More

BMC ANESTHESIOLOGY, vol.18, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2018
  • Doi Number: 10.1186/s12871-018-0513-9
  • Journal Name: BMC ANESTHESIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Procaine, Rats, Knee joint, Intra-articular injections, Local anaesthetics, LOCAL-ANESTHETICS, INTRAARTICULAR INJECTION, IN-VITRO, BUPIVACAINE, LEVOBUPIVACAINE, PAIN, MITOCHONDRIA, APOPTOSIS, LIDOCAINE, THERAPY
  • Hacettepe University Affiliated: Yes

Abstract

Background: Intra-articular local anaesthetics are widely used for providing postoperative analgesia and decreasing the need for opioids. Procaine has proven positive effects in carpal tunnel syndrome and chondromalacia patella. However, the effect of procaine on articular cartilage has not yet been studied. The aim of this study was to evaluate the effects of intra-articular procaine injection on the articular cartilage and the synovium.