Aligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration

Demirbilek M., Sakar M., Karahaliloglu Z., Erdal E., YALCIN E., Bozkurt G., ...More

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.43, no.4, pp.243-251, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3109/21691401.2013.875033
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.243-251
  • Keywords: aligned scaffold, bacterial PHBV, peripheral nerve regeneration, regenerative medicine, GLIAL GROWTH, GAP REPAIR, SCAFFOLDS, HYDROXYBUTYRATE, COLLAGEN, ACID, TUBE
  • Hacettepe University Affiliated: Yes


The conventional method of peripheral nerve gap treatment is autografting. This method is limited. In this study, an aligned nanofibrous graft was formed using microbial polyester, Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The regenerative effect of the graft was compared with that of autografting in vivo. To determine the regenerative effect, rats were assessed with sciatic nerve functional index, electromyographic evaluation, and histological evaluation. Results found in this study include PHBV grafts stimulated progressive nerve regeneration, although regeneration was not comparable with that of autografting. We conclude that the study results were promising for aligned bacterial polymeric grafts for peripheral nerve regeneration.