Background/purpose: Dental implants have been a popular treatment for replacing missing teeth. The purpose of this study was to investigate the impact of engaging (hexagonal) and non-engaging (non-hexagonal) abutments in various six-unit fixed prosthesis on the stress distribution and loading located in the implant neck, implant abutment, and surrounding bone. Materials and methods: Three implants were digitally designed and inserted parallel to each other in edentulous sites of the maxillary right canine, maxillary right central incisor, and maxillary left canine. Titanium base engaging abutments, non-engaging abutments and connecting screws were designed. Five distinct models of 6-unit fixed dental prosthesis were created, each featuring different combinations of various abutments. Forces (45-degree angle) were applied to the prosthesis, allowing for the analysis of the stress distribution on the implant neck and abutments, and the maximum and minimum principal stress values on the cortical and trabecular bone. Results: Von Mises stress values and stress distributions located in the implant neck region due to the applied loading forces were analyzed. The overall stress values were highest while employing the hexagonal abutments. The maxillary left canine with a hexagonal abutment (model 5) reported the highest von mises value (64.71 MPa) while the maxillary right canine with a non-hexagonal abutment (model 4) presented lowest von mises value (56.69 MPa). Conclusion: The results suggest that both the various abutment combinations (engaging and non-engaging) on five different models have a similar influence on the distribution of stress within the implant system.