ALERGOLOGIA POLSKA-POLISH JOURNAL OF ALLERGOLOGY, cilt.10, sa.1, ss.63-67, 2023 (SCI-Expanded)
Hereditary angioedema type 1 (HAE-1) is the most prevalent HAE type, and it results from decreased antigenic
C1 inhibitor (C1-INH) levels or function. Bradykinin-mediated angioedema in the face, trunk, extremities,
genitalia, gastrointestinal tract, and upper airway are the symptoms of this rare and potentially fatal disease.
PD-C1-INH concentrates, recombinant C1-INH, tranexamic acid (TXA), danazol, icatibant, ecallantide, and
fresh-frozen plasma (FFP) may be used for treatment. The focus of this article is to point out D-dimer elevation
during TXA use. We detected d-dimer elevation incidentally in 2 patients with hereditary angioedema (HAE)
type 1 during tranexamic acid (TXA) therapy, in whom elevations were normalized a week after suspended
TXA. However, the TXA treatment is expected to decrease D-dimer levels in surgery and hyperfibrinolysis.
On the other hand, although using TXA in long-term prophylaxis in HAE treatment is not recommended, we
observed that 2 patients had significant reduction of their attack frequency for over a year.