CD-34 selected hematopoetic stem cell transplantation from HLA identical family members for fanconi anemia

Balci Y. I., Akdemir Y., GÜMRÜK F., ÇETİN M., Arpaci F., Uckan D.

PEDIATRIC BLOOD & CANCER, vol.50, no.5, pp.1065-1067, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1002/pbc.21424
  • Journal Name: PEDIATRIC BLOOD & CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1065-1067
  • Hacettepe University Affiliated: Yes

Abstract

Hematopoetic stem cell transplantation, even from an HLA 6/6 identical family member is associated with an increased frequency of complication in fanconi anemia (FA). The increased susceptibility for chromosomal breaks has been suggested as a contributory factor for increased risk of toxicity, graft versus host disease (GVHD) and increased incidence of post-transplant solid tumors. Therefore, non-irradiation based preparative regimens usually containing fludarabine and T-cell depletion of HLA genoidentical bone marrow cells have increasingly been used in patients with FA. Here, we report three children with FA who underwent CD-34 selected HSCT from HLA-identical family donors with reduced intensity fludarabine-based regimen.