The Effect of Nitrogen Mustard on the Rat Brain and the Therapeutic Value of Proanthocyanidin

Tekiner A., Yucel O., Sargin A. K., Genc O., Can B., Karayilanoglu T., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.19, sa.4, ss.360-366, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.360-366
  • Hacettepe Üniversitesi Adresli: Evet

Özet

AIM: Nitrogen Mustard (NM) is an alkylating agent that damages cellular nuclear DNA after penetrating tissue. This results in cytostatic, mutagenic and cytotoxic effects. We used the electron microscope to investigate the effect of NM gas administered through the dermal and respiratory routes to rats on the brain cortex and also tried to show whether the antioxidant Proanthocyanidin (PC) could decrease this effect.