Amphiphilic cyclodextrin derivatives for targeted drug delivery to tumors


ERDOĞAR N., VARAN G., BİLENSOY E.

Current Topics in Medicinal Chemistry, cilt.17, sa.13, ss.1521-1528, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 13
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1568026616666161222101104
  • Dergi Adı: Current Topics in Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1521-1528
  • Anahtar Kelimeler: Amphiphilic, Cyclodextrin, Drug delivery, Folate, Polycationic, Targeting, PROTEIN-KINASE CK2, CONJUGATED BETA-CYCLODEXTRIN, IN-VITRO, ANTICANCER DRUG, GENE DELIVERY, QUANTUM DOTS, STRUCTURAL MODIFICATIONS, FORMULATION DEVELOPMENT, NANOPARTICLES, DOXORUBICIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

© 2017 Bentham Science Publishers.Villiers has extensively studied cyclodextrins, a family of macrocyclic oligosaccharides linked by α-1,4 glycosidic bonds, in different fields since their discovery in 1891. The unique structure enabling inclusion complexation for natural cyclodextrins and cyclodextrin derivatives make them attractive for novel drug delivery systems. Cyclodextrins can be modified with long aliphatic chains to render an amphiphilic property and these different amphiphilic cyclodextrins are able to form nanoparticles without surfactants. In the literature, several different amphiphilic cyclodextrins are reported and applied to drug delivery and targeting especially to tumors. Specificly, folateconjugated amphiphilic cyclodextrin derivatives are used for active tumor targeting of poorly water soluble drugs and improve the efficacy and safety of therapeutic agents. On the other hand, effect of positive surface charge has also been under research in the recent years. Polycationic amphiphilic cyclodextrins have shown promise towards forming small complexes with negatively charged molecules such as drugs or plasmid DNA. Polycationic amphiphilic cyclodextrins enhance interaction with cell membrane due to their net positive surface charge. The scope of this review is to describe potential uses and pharmaceutical applications of tumor-targeted amphiphilic cyclodextrins, with focus on folate-conjugated cyclodextrin derivatives and polycationic cyclodextrin derivatives both studied by our group at Hacettepe University.