The Cardiopulmonary Effects of Calcitonin-Gene Related Peptide Family Kalsitonin-Geni İle İlişkili Peptit Ailesinin Kardiyopulmoner Etkileri
Turkish Journal of Pharmaceutical s, vol.17, pp.349-356, 2020 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Review
- Volume: 17
- Publication Date: 2020
- Doi Number: 10.4274/tjps.galenos.2019.47123
- Journal Name: Turkish Journal of Pharmaceutical s
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.349-356
- Keywords: CGRP family, cardiopulmonary diseases, adrenomedullin, adrenomedullin2, intermedin, pulmonary hypertension, VASCULAR SMOOTH-MUSCLE, PULMONARY ARTERIAL-HYPERTENSION, ACTIVITY-MODIFYING PROTEINS, INCREASED PLASMA-LEVELS, CENTRAL-NERVOUS-SYSTEM, NITRIC-OXIDE, REGIONAL HEMODYNAMICS, SIGNAL-TRANSDUCTION, ENDOTHELIAL-CELLS, DEPENDENT PATHWAY
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
Cardiopulmonary diseases are very common among the population. They are high -cost diseases and there are still no definitive treatments. The roles of members of the calcitonin-gene related -peptide (CGRP) family in treating cardiopulmonary diseases have been studied for many years and promising results obtained. Especially in recent years, two important members of the family, adrenomedullin and adrenomedullin2/intermedin, have been considered new treatment targets in cardiopulmonary diseases. In this review, the roles of CGRP family members in cardiopulmonary diseases are investigated based on the studies performed to date.