B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy

Eroglu F. K., Kaya F. S. F., Cagdas D. N., Ozgur T. T., Yılmaz T., Tezcan I., ...Daha Fazla

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, cilt.88, sa.4, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/sji.12709
  • Dergi Adı: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: B lymphocyte subsets, hypogammaglobulinemia, memory B cells, transient hypogammaglobulinemia of infancy, COMMON VARIABLE IMMUNODEFICIENCY, REFERENCE VALUES, CELL SUBPOPULATIONS, CYTOKINE PRODUCTION, CHILDREN, CLASSIFICATION, DEFICIENCIES, BLOOD
  • Hacettepe Üniversitesi Adresli: Evet

Özet

PurposeTransient hypogammaglobulinemia of infancy (THI) is a common immunodeficiency, but definitive diagnosis can only be made retrospectively. While the pathogenesis is still unknown, abnormalities have been reported in the B cell compartment. In this study, we analysed the B cell subsets of patients with an initial THI diagnosis (n=20) and compared them with those of healthy age-matched Turkish children (n=72).