Pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab

Kalyoncu U., Karadag O., Akdogan A., KISACIK B., Erman M., Erguven S., ...Daha Fazla

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, cilt.39, sa.5, ss.475-478, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 39 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/00365540601071867
  • Dergi Adı: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.475-478
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Patients with rheumatoid arthritis (RA) have an increased risk of infection as a result of alterations in immune regulation, debility, and comorbid illnesses. TNF-alpha is of central importance in the pathophysiological responses to infection and inflammation, and plays a crucial role in host defence. Pneumocystis carinii is an opportunistic pathogen that commonly affects individuals with inadequate T-cell mediated immune response. Patients with acquired immune deficiency, as well as those receiving immunosuppressive drugs for various conditions have an increased risk of P. carinii pneumonia (PCP). We report the development of PCP in a woman with RA shortly after the initiation of anti-TNF-alpha treatment with adalimumab.