Associations between toxic elements and blood pressure parameters in adolescents

YALÇIN S. S., Erdal I., OĞUZ B., DÜZOVA A.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.71, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.jtemb.2022.126949
  • Dergi Adı: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Hypertension, Toxic elements, Ambulatory blood pressure, Carotid intima-media thickness, Non-dipping, CARDIAC AUTONOMIC ACTIVITY, INTIMA-MEDIA THICKNESS, CARDIOVASCULAR-DISEASE, LEAD-EXPOSURE, EUROPEAN-SOCIETY, ARSENIC EXPOSURE, FOLLOW-UP, CHILDREN, CADMIUM, MERCURY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Both exposure to toxic elements and hypertension (HT) are a global health problem. We planned to examine the associations between some toxic elements in urine, and blood pressure (BP) and its diurnal changes in adolescents. Methods: In this cross-sectional study, 48 adolescents who were newly diagnosed with HT and 38 adolescents with age-appropriate BP and normal physical examination were included. Anthropometric measurements, urinary toxic elements, carotid intima media thickness (cIMT), and office and 24-hour ambulatory BP measurements (ABPM) of participants were taken. Urinary elements levels were studied with ICP-MS. Elements were grouped in tertiles according to urinary levels. Logistic regression analyses were performed to show the interactions. Results: Urinary cadmium, mercury, lead, and arsenic were found to be at detectable level in 90.7%, 69.8%, 91.9% and 100% of the participants, respectively. Univariate analyses showed that elevated daytime systolic and/or diastolic BP was associated with urinary cadmium and mercury. No association between urinary toxic elements and nighttime BP was found. When height and body mass index z-scores adjusted for, age, gender, and all four urinary creatinine-corrected toxic elements analyzed, multiple logistic regression revealed that there was an association between mercury (high vs. low; AOR:3.85) and office HT, and mercury (high vs. low; AOR:6.18) and cadmium (middle vs. low; AOR: 13.38) were associated with "elevated 24-hour systolic BP and/or diastolic BP", and "elevated 24-hour mean arterial BP" in ABPM. Conclusion: There are complex relationships between toxic elements and BP parameters in adolescents, and more studies are needed to define the evolution of these relations.