Pyrazoline-based Mycobactin Analogues as Dual Inhibitors of MAO/Cholinesterase

Jayaprakash V., YABANOĞLU ÇİFTÇİ S., Sinha B. N., UÇAR G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.35, no.2, pp.89-96, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 2
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.89-96
  • Hacettepe University Affiliated: Yes

Abstract

Introduction: We earlier reported on anti-mycobacterial and monoamine oxidase (MAO) inhibitory activity of 3, 5-diaryl-2-pyrazoline 1-carbothioamides with structural similarities to Mycobactin. The same thirty two compounds have been evaluated for Acetylcholinesterase (AChE) inhibitory activity in a search for dual inhibitors against MAO-B/AChE which may have potential therapeutic utility in Alzheimer Disease (AD).