5-Androstene-3 beta,17 beta-diol Promotes Recovery of Immature Hematopoietic Cells Following Myelosuppressive Radiation and Synergizes With Thrombopoietin


Aerts-Kaya F. S. F. , Visser T. P. , Arshad S., Frincke J., Stickney D. R. , Reading C. L. , ...More

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.84, no.3, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ijrobp.2012.04.021
  • Title of Journal : INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Abstract

Purpose: 5-Androstene-3 beta,17 beta-diol (5-AED) stimulates recovery of hematopoiesis after exposure to radiation. To elucidate its cellular targets, the effects of 5-AED alone and in combination with (pegylated) granulocyte colony-stimulating factor and thrombopoietin (TPO) on immature hematopoietic progenitor cells were evaluated following total body irradiation.