Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model


Orunoğlu M., Kaffashi a., PEHLİVAN S. , ŞAHİN S. , SÖYLEMEZOĞLU A. F. , KARLI OĞUZ H. K. , ...More

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol.78, pp.32-38, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78
  • Publication Date: 2017
  • Doi Number: 10.1016/j.msec.2017.03.292
  • Title of Journal : MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
  • Page Numbers: pp.32-38

Abstract

Background: Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles.